The Buffett of Biotech's Portfolio

Through Opko Health, billionaire Dr. Phillip Frost (see main story) is building a health-care-focused Berkshire Hathaway, but like other great investors, he finds values in a myriad of industries. Below are 20 Frost-owned companies, nearly all publically traded, but most are highly risky micro-caps.

OPKO HEALTH (OPK) Frost owns 34% of therapeutics and diagnostics company with $1.2 billion in sales.

TEVA PHARMACEUTICALS INDUSTRIES (TEVA) A $20 billion (revenue) Israel-based big pharma, specializing in generics. Frost owns 1.5% of the stock.

VECTOR GROUP (VGR) Founded by fellow Philadelphian Bennett LeBow; owns tobacco company Liggett Group and commercial realtor Douglas Elliman Realty. Frost is largest shareholder, with 15%.

LADENBURG THALMANN (LTS) Regional investment bank and financial advisory; 4,000 advisors and $132 billion in assets. Frost owns 36.5% and Vector Group owns 8.23%.

CASTLE BRANDS (ROX) Maker of premium liquor, including Jefferson's whiskey and Goslings rum. Frost owns 33.5% and Vector 8%.

COCONUT GROVE BANKSHARES (Private) Miami-Dade's oldest bank; Frost owns 24%.

COGINT (COGT) Formerly Tiger Media; a cloud-based data and analytics company focused on marketing and risk management. Frost owns 29%.

BIOCARDIA (Private, Owned by Opko) Formed by Frost's Sorbonne roommate, Dr. Simon Stertzer. A clinical-stage company using stem cells to repair cardiac muscle after a heart attack. Frost owns 32.7%.

DRONE AVIATION (DRNE) Florida-based maker of drones for law enforcement and military. Frost owns 14%.

ARNO THERAPEUTICS (ARNI) Developing antiprogestins for breast, endometrial and prostate cancers. Opko owns 9%.

ZEBRA BIOLOGICS (Private, Owned by Opko) Attempting to make generic versions of antibody drugs--like the bestselling rheumatoid arthritis drug Humira--that could be better than the original. Opko owns 29%.

OAO PHARMSYNTHEZ (Private, Owned by Opko) Russian developer and marketer of new drugs in Eastern Europe. Opko owns a 17% equity interest.

RXI PHARMACEUTICALS (RXII) Ladenburg took it public in December. Developing an RNA interface to prevent skin scars. Opko has an 19% equity interest.

COCRYSTAL PHARMA (COCP) New antivirals (hepatitis C, flu, Norovirus); Frost and Opko own 23%.

SEVION THERAPEUTICS (SVON) Developing antibodies against difficult targets; treating cancer and immunological diseases. Frost and Opko own 20%.

NEOVASC (NVCN) Canadian maker of specialized cardiology devices. Frost owns 22%.

CHROMADEX (CDXC) Maker of ingredients for nutritional supplements. Frost owns 14.6%.

VBI VACCINES (VBIV) Developing a technology platform to design vaccines for hepatitis B, Zika and brain tumors. Opko has a 25% equity interest.

MABVAX THERAPEUTICS (MBVX) Clinical-stage cancer immunotherapy. Frost and Opko have an estimated 5% interest.

MUSCLEPHARM (MSLP) Nutritional supplements. Frost owns less than 5%.

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