U.S. stock index futures tumbled Friday as results from Thursday's referendum showed the U.K. had voted to leave the European Union (EU).
Dow Jones futures broke below an implied open down more than 700 points overnight, before paring losses to show an implied open down around 450.
The referendum result stunned markets, which had expected the U.K. to vote to remain in the EU. The leave camp secured 51.9 percent of the vote.
London's benchmark FTSE 100 stock index accelerated losses after it opened at 3 a.m. ET to trade as much as 7.9 percent lower, before trading about 5 percent lower. The French CAC traded 7.3 percent lower and the German DAX was down 6.2 percent.
At around 3:30 a.m. ET, U.K. Prime Minister David Cameron, who campaigned for the remain vote, announced his intention to resign by October.
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