U.S. stock-index futures traded lower on Wednesday, ahead of swathes of big-name earnings and a Federal Reserve policy decision.
Companies that reported quarterly results early in the day included Comcast, and United Technologies Corporation. Comcast is said to be in talks to acquire Dreamworks Animation in a $3 billion deal.
Facebook will post numbers after Wall Street closes.
Pending home sales data will be out on Wednesday, along with the weekly MBA Mortgage Index and crude inventories.
The Federal Open Market Committee (FOMC) rate decision for April is due at 2 p.m. ET. No interest rate hike is expected, although the possibility of one in June may be flagged.
"The o/n (overnight) Fed funds rate will be held steady and the focus shall be on the continued strength in the labor markets, while there shall be continued discussions regarding the weakness in the economies abroad and thus the need to hold policy steady," market commentator, Dennis Gartman, said in The Gartman Letter on Tuesday.
Shares in Apple fell by more than 8 percent in after-hours trading on Tuesday after the company reported quarterly earnings and revenue that missed analysts' expectations. Its guidance for the current quarter also missed forecasts.
A customer compares the iPhone SE (left) and the iPhone 6S (right) at an Apple Store in Hangzhou, China.
Apple GAINED smartphone market share in this Chinese sector
In other news, presidential candidates, Donald Trump and Hillary Clinton, pulled ahead of rivals in Tuesday's primary contests in Pennsylvania, Maryland, Connecticut, Rhode Island and Delaware.
WTI and Brent crude oil futures extended gains in Asia overnight, following a reported drop in U.S. inventories.
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